It couldn't be more different for Chelsea and Arsenal
Do or die, that's the dilemma facing Andre Villas-Boas's side on a night when London rivals Arsenal have the luxury of knowing their place in the last 16 is guaranteed.
As it stands, a win would guarantee the Blues passage, a scoreless draw would also be enough due to the fact that their head-to-head has Chelsea with an away goal from a 1-1 draw in Spain.
A spirited win away to Newcastle at the weekend will boost the morale ahead of this must win clash. It was their first win and first clean sheet in five games, but a shroud of controversy overshadowed the game as David Luiz should have been dismissed early. But as it stands, Chelsea have a win. However as it stands Chelsea, in their last six games against Spanish sides the Blues have five draws, yet they have never lost against Valencia.
Should Chelsea (3/4) fail to make the last 16 and find themselves in the Europa League, there would undoubtedly be calls for Villas Boas resignation. The pressure on the young manager must be immense and this could inspire a good performance from his side.
Valencia (19/5) had a better goals record than their opponents and they will be relying on Roberto Soldado to bag some goals. The striker has 14 goals so far this season, that's eight more than Chelsea's top scorer Daniel Sturridge. No surprise that Soldado is 15/8 to score at anytime and he is 13/2 to open the scoring.
Juan Mata is facing his old club for the second time and we have centered our match winner around the midfielder. Enhanced from 11/4 we are offering you Mata to score at anytime and Chelsea to win at 7/2.
A 0-0 draw, which would take Chelsea through is 10/1 while a 1-1 draw, which could see them dumped out is 13/2.
Daniel Sturridge has proved to be one of the best young strikers in the Premier League and has singlehandedly carried the West Londoners. He is 5/1 to open the scoring and 5/4 to score anytime. Ironically Torres is the only Chelsea player to score more than two in this year's competition and he is 6/4 to score at anytime.
David Luiz is a potential liability, his tackling has been rash and clumsy and he may sit on the bench but if he were to be involved, get on a red card to be shown or a penalty to conceded.
Arsenal may be through already, but their opponents are still chasing that second qualifying spot. They host the Gunners knowing that realistically only a win will see them through. The Greeks are 5/6 to get the win they need and Arsenal are 10/3, reflecting the fact that for them this is a dead rubber.
Arsenal are a tough side to break down and I can see them being quite resolute for the first half, therefore at 7/2 I think Draw/Olympiacos is well worth considering.
The home form of Olympiacos is quite impressive when you take into account that they had 17 consecutive victories in the league at Karaiskakis Stadium.
Serbian journeyman Marko Pantelic has made his home in the Olympiacos strike force and has scored in 13 games, all of which ended in Olympiacos victories. An anytime wincast on Pantelic to score and his side to win is a 13/5 shot.
Marouane Chamakh is likely to start for the visitors and he is a 10/1 shot to open the scoring. But I envisage a high scoring game and at 5/4, I'd be on the over 2.5 goals. Also both teams to score at 21/20 looks to be another cert.