No shock on the cards in Cardiff
Defending Six Nations champions Wales welcome England to the Millennium Stadium in the second round of matches.
Warren Gatland's Welsh side are massive favourites to beat Martin Johnson's English side at odds of 2/9. A shock away win is a big 11/4 with the draw at 20/1.
Wales were impressive in victory last week at Murrayfield, they could even afford to take their foot off the gas in the latter stages such was their dominance.
England on the other hand despite a comprehensive 36-11 victory at Twickenham against Italy were far from convincing.
England took advantage of emergency scrum-half Mauro Bergamasco's mistakes which cost the Italians three first-half tries, effectively putting the game out of reach of Nick Mallett's side.
Once again the old English problems of a lack of cutting edge and imagination in the back-line was evident, yet this was never going to be solved by picking the solid but unspectacular Andy Goode at fly-half.
Goode retains his place in the starting XV against Wales but Leicester's Toby Flood has returned from injury to replace London Irish's Shane Geraghty on the bench.
Another recent England trait was in evidence again last week, that of conceding penalties. Twice Johnson's side were down to fourteen men with James Haskell and Geraghty both shown yellow cards.
If the indiscipline is continued on Saturday then Wales will no doubt take England apart with their effective backs.
Star man Shane Williams though is an injury doubt. The Ospreys winger has been named in the starting line-up but needs to pass a fitness test before he can take his place in the team.
If Williams and back-rower Andy Powell pass their fitness tests then the only change to the line-up will be the return of captain Ryan Jones, who had to pull out shortly before the Scotland match, after failing a fitness test.
As is to be expected Williams is the favourite at 7/1 to score the first try, 11/10 to score one at anytime. However, scrum-half Mike Phillips looks like value at 20/1 to go over first.
For England both Mark Cueto and Paul Sackey are 14/1 shots to get the first five-point score and are priced at 9/4 to grab a try during the match.
Sale back Matthew Tait will start on the bench for England but if the game is not going England's way then Tait will no doubt be utilised reasonably early.
He is 7/2 to score a try and given his history in the Millennium Stadium when he was taught a harsh lesson by Gavin Henson on his international debut way back in 2005, you wouldn't back against him making amends.
Mike Tindall and Joe Worsley return to the England side replacing Jamie Noon at outside-centre and Steffon Armitage at open-side flanker respectively from last week's side.
But these two changes in personnel are unlikely to make much difference to England.
The visitors receive a 10 point start on the handicap with both sides available at 10/11 and on the evidence of last week there can only be one team to back on the handicap and it is not Martin Johnson's side.
Despite Johnno's best efforts so far his England side has generally fallen well short of the required standard. Questions still remain whether the 2003 World Cup winning captain is the right man to lead his country with his lack of coaching experience.
The RFU still hope that his inspirational leadership will rub off on the current crop of players and that the former Leicester man will turn into as good a coach as he was captain.
Perhaps the best thing Johnson could do is replace captain Steve Borthwick as doubts remain whether he should even be in England's best XV but nevertheless Johnson has continued to back the Saracens lock.
You can see if England can turn around their fortunes live on BBC One from 17:30 on Saturday and of course our betlive service will be available from then also, offering a wide range of markets to bet on throughout the match.
And if you've not already seen, we're running our "buy one, get one free" offer again this weekend - simply place a First Try Scorer bet on this or the France v Scotland clash, and we'll match it with a free bet to the same stake on the Italy v Ireland First Try Scorer. Click here for full details.