FA Cup

Southampton vs Arsenal Prediction: Can Gunners Stop Saints From Marching?

2 hours ago

| BY Sam Cox

Arsenal are fighting on multiple fronts and the Gunners are clear favourites with William Hill to advance past Southampton in the FA Cup quarter-finals this weekend.

Here are our football betting tips for Saturday night’s clash, with Mikel Arteta’s side looking to bounce back following a dismal performance in the 2025/26 League Cup final prior to the international break.

Southampton vs Arsenal Odds:

Southampton – 17/2
Draw – 4/1
Arsenal – 2/7

Southampton are unbeaten in 14 matches with 11 wins in that period. They have knocked Fulham and Leicester out of the FA Cup in the last two rounds and have only lost once at home since Nov. 1.

Arsenal entered the international break with a meek showing in the Carabao Cup final. Faint hopes of a quadruple have been extinguished, and the Gunners could see another piece of silverware ruled out this weekend.

Arsenal only beat Mansfield by one goal in the last round and have drawn away to Brentford, Wolves, and Bayer Leverkusen since the start of February. While deservedly favoured, this is far from a foregone conclusion with the vulnerability Mikel Arteta’s side have shown in 2026.

Like Liverpool, next week’s Champions League tie is going to be on the minds of Arsenal’s players and staff. Southampton aren’t going to roll over – they are high on confidence and have been formidable in front of their own fans this season.

This could end up being a tense evening for Arsenal. Don’t be surprised if the Saints force this to extra time.

Southampton vs Arsenal prediction: Match to end a draw (4/1)