The NFL schedule this week has some thrilling games to keep an eye on. We preview them below and guide you through some of the best bets in week four of the new season, alongside our ambassador Jason Bell.

New York Giants @ Los Angeles Rams

The New York Giants are experiencing a very tough season, with stud running back Saquon Barkley out for the campaign and second-year signal caller Daniel Jones experiencing some struggles, as they sit on an 0-3 record already.

Los Angeles Rams almost staged a hugely impressive comeback against Buffalo Bills last week, before being undone by a late drive involving a controversial pass interference call. The offence is starting to click again, while the defence retains the ability to get after anybody if Aaron Donald is on form.

The Rams are just 1/8 to get the home win on Sunday, while New York are a huge 11/2. The handicap sits at 13, and expect LA to run riot, comfortably beating the two-score spread at 10/11. For fans of a value bet, the Rams by 31+ in a blowout is 13/2.

New England Patriots @ Kansas City Chiefs

Two MVP winning quarterbacks go head to head on Sunday as the New England Patriots visit Arrowhead. This year sees Cam Newton at the helm of the Patriots offense, while Patrick Mahomes continues to add to his already impressive legacy. A dismantling of the Baltimore Ravens earlier this week has ensured the Chiefs’ Super Bowl credentials only get stronger, while Cam and the Patriots bounced back with a good win over a strong Las Vegas Raiders side.

The visiting New England outfit are 5/2, while the hosts are 1/3. While the Patriots defence has had some opt-outs, it is still one of the elite units in the league, with ballhawks all over the secondary, so it wouldn’t be a surprise to see Mahomes struggle early. With the handicap sitting at 7, it might be a shrewd bet to see Kansas win by 1-6, which is available at 3/1.

Buffalo Bills @ Las Vegas Raiders

Josh Allen’s Buffalo Bills roll into Vegas to take on the Las Vegas Raiders in another late Sunday clash, and on paper this should be a cracker. Two good offences, quarterbacks that can sling it deep and some of the best young talent in the league on show should make for excellent viewing. The Bills will have their sights on another play-off berth, while the Raiders will be hoping to crack the post-season for the first time since 2016.

Buffalo are rightly favourites for this at 10/17, with Las Vegas at 6/4, but Derek Carr already has the scalp of New Orleans Saints at the new Allegiant Stadium, and will be looking to keep that unbeaten home record.

It should be an excellent game to watch, and could be one for the over points total of 52.5 at 10/11.

Check out all the latest NFL betting odds at William Hill