Domestic football took a back seat for the final instalment of Euro 2020 qualifiers but this weekend focus reverts back to the Premier League.

There’s a London derby baptism of fire for new Tottenham manager Jose Mourinho at West Ham, while Arsenal and Southampton could be fighting it out for the fates of their two managers. We preview some of the Premier League’s key action below.

Mourinho to start Tottenham tenure with a bang

Following Mauricio Pochettino’s recent dismissal, Jose Mourinho is now the man tasked with turning Tottenham’s league form around, starting with West Ham away on Saturday, for which they are 3/4 favourites.

The sides go into the game separated by a single point, with the Hammers looking for their first win since overcoming Manchester United back in September and Spurs seeking their first away league win in 13 games. Tottenham sit 14th, with West Ham two places below in 16th.

That said, there’s nothing like a new manager and a London derby to inspire the troops and, with ability aplenty, this could be the game to reverse their recent fortunes and move them up in the table. A Spurs win with both teams to score is available at 19/10.

The goals have come thick and fast for Harry Kane in the Euro 2020 qualifiers and he has notched 20 in all competitions this season, not to mention having scored two in his last two league visits to the London Stadium. Take advantage of the enhanced odds on offer for Kane to score two goals or more at a price of 5/1.

Emery and Hasenhuttl face crunch clash

With both Arsenal and Southampton under immense pressure to reverse their recent ruts, this clash at the Emirates Stadium may carry huge weight for the destinies of their respective managers. At 6/4 and 2/1 respectively, Unai Emery and Ralph Hasenhuttl are the top two in the Premier League sack race and could each do with a result to ease the burden.

Despite Arsenal being unbeaten at home this season, they are without a win in four league games, while Southampton have only managed to take one point from their last 21 available.

The Saints, who pulled it back to 1-1 against Everton last time out before succumbing to a 75th minute Richarlison winner, were booed at the end of each half at St Mary’s in that game and will surely want to put on a more convincing display for their travelling fans here on Saturday.

The Gunners have only kept two clean sheets in the Premier League this season, which will give the south coast outfit encouragement. A drawn first half and Arsenal to win the second half at 7/2 looks a good value bet, with the Gunners the 47/100 favourites for the three points.

Liverpool to maintain fine start

Not that they needed a boost, but Liverpool will be flying higher than ever after beating title rivals Manchester City in their last league game.

Next up is a trip to the capital to take on a mid-table Crystal Palace side on Saturday, which will give the Reds an opportunity to extend their season-long Premier League unbeaten run even further. It’s little surprise that Jurgen Klopp’s men go into the game as 42/100 favourites for the three points.

While that may not appeal, enhanced odds on Liverpool to win both halves are now 11/4, from a previous 12/5, and that certainly holds value.

They found the back of the net within six minutes against City and went into the break 2-0 up, and there is little to suggest that Liverpool won’t at least be as clinical here at Selhurst Park.

With Liverpool scoring 12 goals in their last four games, there could be a potential drubbing on the cards and four total match goals can be backed at 4/1, though they could be without talisman Mohamed Salah who is struggling for fitness.

Check out all the latest football betting odds at William Hill.