The third round of fixtures in this year’s Six Nations concludes with the game of the weekend as Ireland travel to Twickenham to take on England. Here is our preview of Sunday’s encounter.

Injuries a worry for Jones

With both Mako and Billy Vunipola sidelined through injury, it’s no surprise to see England’s price to beat Ireland on Sunday take a slight wobble from 1/3 to 4/11 this week. The brothers continually carry England over the gain line, and though England have coped thus far without bruising number eight Billy, the loss of top-class prop Mako is another big blow.

However, it’s not all bad news in the Red Rose camp, with Henry Slade and Manu Tuilagi set to return. Tuilagi can be guaranteed to carry hard up the middle of the pitch and that’s exactly what England will need to get themselves a foothold into this crucial game.

Ireland +7 looks the value call at Evens but there’s a few more interesting punts to be had this weekend…

Monster odds on offer with game too close to call

Conditions at Twickenham are set to be much fairer than those experienced at Murrayfield a fortnight ago. Kicking penalties, slotting conversations and playing any sort of expansive rugby was put to the test in galeforce gusts and pouring rain last weekend. It was no surprise that a total of just 19 points were scored and you’d expect the scoreboard to be busier here.

The first half is likely to still be a very tight affair, with Ireland’s defence looking extremely steady so far, and 10/1 on it being all square at half-time is a nice speculative bet. After that, the game really could swing either way.

England may run out of options, become frustrated and lack any real firepower off the bench to pose much danger. Meanwhile, Ireland have looked very strong defensively but toothless in attack, so it could be worth concentrating on other markets outside of the outrights.

Jonny May is unarguably England’s most electric player and he’s a fanciable 11/10 to add to his tally of two tries this tournament at anytime. The Leicester flyer has is quick, powerful, kicks well and is as lethal a finisher as anyone in the tournament this year.

Ireland could have last laugh

Another interesting one is the last scoring play market. As is often the case with these hard-fought, patriotic battles, sides will continue fighting right to the bitter end. Ireland are 5/4 to get the last laugh and score the final try of the match.

Check out all the latest rugby union betting odds at William Hill.