NFL Sunday Week 4 Best Bets: Bills & 49ers Continue Hot Streak And Head 5/1 Accumulator

Week 4 has a proper Sunday slate with a few games that could shape the early-season picture in both conferences and William Hill News bring you the best of the action in this NFL betting preview.

The numbers are tight in a lot of places, which usually means the better quarterback play, cleaner situational football, and a couple of key matchups up front will decide things.

NFL Sunday Week 4 Betting Tips

• Buffalo Bills to win by 7 points or more (4/5)
• Minnesota Vikings to win (1/8)
• Kansas City Chiefs to win (4/9)
• San Francisco 49ers to win (4/6)
• Seattle Seahawks to win (1/4)

That is exactly the sort of weekend where friends text each other all afternoon, debate every drive, and pretend one bad fourth-down call did not ruin their mood.

Buffalo Bills vs New England Patriots Prediction

Buffalo comes in as the clear class of the AFC East early on, and the market has backed that up with the Bills installed as heavy favourites.

Their offence has been the most productive in the league through three weeks, and the Patriots are walking into a tough spot after a rough defensive outing against Jacksonville. The Bills have too many ways to score, and at home they can lean on tempo and balance rather than forcing anything.

New England’s best route is to make this messy and keep it within one score for as long as possible. That means avoiding turnovers and getting Josh McDaniels-style control of the clock through the ground game and short passing.

Still, Buffalo has looked too sharp and too complete to trust against. The Bills should pull away in the second half and keep control late.

Score prediction: Bills 31, Patriots 20

Minnesota Vikings vs Miami Dolphins Prediction

Minnesota is one of the week’s biggest favourites, and this is a bad stylistic spot for Miami. The Vikings have been built to create chaos, with a defence that forces quarterbacks into quick decisions and uncomfortable reads.

That matters even more against a Dolphins team that has leaned heavily on the run and has not shown much margin for error if the script turns against them.

Miami needs a clean day from the offensive line and enough explosive plays to avoid getting dragged into a long possession-by-possession grind.

That is easier said than done in Minneapolis. If Minnesota gets early pressure and a lead, the game can tilt fast. The Dolphins are good enough to land a couple of punches, but not enough to win the field-position fight for four quarters.

Score prediction: Vikings 27, Dolphins 16

Las Vegas Raiders vs Kansas City Chiefs Prediction

This is one of the more interesting games on the board because the Raiders have started 3-0 and the Chiefs have not exactly looked like a team just trying to survive the regular season – this is a key context to the destiny of the AFC West division.

Kansas City still brings the better quarterback, the cleaner late-game habits, and the more reliable defence in a game that should tighten up once the first scripted drives are gone.

Las Vegas has earned respect by finding ways to win, but this is where the degree of difficulty jumps. Patrick Mahomes usually gives Kansas City a clear edge in games that turn into chess matches, and the Raiders will need near-perfect execution to keep him from controlling the pace.

Expect a competitive first half, then the Chiefs to make the crucial plays after the break.

Score prediction: Chiefs 28, Raiders 23

San Francisco 49ers vs Denver Broncos Prediction

San Francisco has been one of the league’s best teams through the opening month, and the underlying numbers back that up. They have been efficient on both sides of the ball, which is exactly why they are such a difficult team to upset at home.

Denver’s comeback win last week was impressive, but this is a very different challenge against a 49ers side that can beat you in multiple phases.

The Broncos will need Bo Nix to handle pressure, protect the ball, and turn red-zone chances into touchdowns rather than field goals. That is a tall order in Santa Clara.

San Francisco’s offence should be able to stay ahead of the sticks and keep Denver chasing. The Broncos can stay awkward for a while, but the 49ers look more complete in every area that matters.

Score prediction: 49ers 30, Broncos 20

Seattle Seahawks vs Los Angeles Chargers Prediction

Seattle enters this one with real momentum and a strong defensive profile, while the Chargers are still trying to stop the season from sliding away.

That creates a simple shape for the game: if the Seahawks get a comfortable lead, the Chargers may not have the passing rhythm or run game to answer quickly enough. Seattle has been the more stable team and the better bet in front of its own crowd.

Los Angeles needs Justin Herbert to produce a near-perfect afternoon, because the margin for error looks thin against a defence that has been hard to move consistently.

Seattle can make this ugly early, win the turnover battle if it gets one, and let the crowd turn every stalled Chargers drive into pressure. That is a dangerous setup for a team already chasing form.

Score prediction: Seahawks 27, Chargers 17

*Odds subject to change – prices accurate at the time of writing*