The headline act of the Premier League weekend comes in the Manchester derby as Manchester City take on Manchester United at the Etihad in a top-of-the-table matchup.

With a host of games on around the country, we take a look at the pick of the fixtures below.

A title decider in the Manchester derby?

Bragging rights are on the line in the Manchester derby on Sunday afternoon. Manchester City continue to roll relentlessly to another Premier League title, thumping Wolves 4-1 on Tuesday to make it 21 straight wins and move 14 points clear at the top of second-placed Manchester United.

The goals are flowing at the Etihad, and the in-form Gabriel Jesus, who has three goals in his last three, is 9/2 to score first in this clash of the top two. United, however, haven’t been beaten away from home in over a year, and their last two games have finished 0-0 – a result they’d probably take here.

But Bruno Fernandes is always capable of popping up with a goal and he is 12/5 to score anytime. City are the favourites for the three points at 1/2, while United are 6/1 to come away with the win. The draw is 16/5.

City’s winning run and United’s unbeaten streak away from home – something has to give. And a victory for Pep Guardiola’s men would surely all but secure the title.

Villa welcome Wolves in bid to secure European qualification

Aston Villa will look to put a shock midweek defeat at the hands of bottom side Sheffield United behind them in this Midlands derby on Saturday. The Villains have enjoyed a fine season so far, but they looked to struggle at Bramall Lane without talisman Jack Grealish, who could be absent once again here.

Sitting in ninth place, Villa still have a chance of finishing in the European spots in the league will want to secure another three point in their push here. Their top scorer Ollie Watkins is 9/2 to score first.

Wolves have seen a resurgence in their form of late, and they only gave way late on when away at Man City on Tuesday. Prior to that defeat they’d tightened up at the back, conceding just four goals in their last seven league games.

Villa are 18/5 favourites to earn the bragging rights, while Wolves are 21/10 to come away with three points. The visitors have proven they can be hard to break down, and the draw is a 11/5 shot.

Seagulls looking to avoid relegation battle as they face Foxes

16th-placed Brighton are in desperate need of three points and they take on a Leicester side on Saturday with the Foxes undergoing a major injury crisis.

The Seagulls somehow came away from the Hawthorns empty-handed last weekend, losing 1-0 to West Brom and missing two penalties in the process. They have been wasteful in front of goal all season and they will need to be more clinical if they are to avoid being dragged into the bottom three.

Leicester, meanwhile, are without several key players, including James Maddison, Harvey Barnes and James Justin. They picked up a battling point away at Burnley on Wednesday, but goals could be few and far between in this one. Under 2.5 goals is a 4/6 shot, while Brighton are slight favourites at 8/5.

Leicester are 19/10, with the draw likely to prove popular at 11/5.

Check out all the latest football betting odds at William Hill